APOE genotype, ethnicity, and the risk of cerebral hemorrhage
Identifieur interne : 008E98 ( Main/Exploration ); précédent : 008E97; suivant : 008E99APOE genotype, ethnicity, and the risk of cerebral hemorrhage
Auteurs : C. Tzourio [France, Australie] ; H. Arima [Japon] ; S. Harrap [Australie] ; C. Anderson [Australie] ; O. Godin [France] ; M. Woodward [Australie, États-Unis] ; B. Neal [Australie] ; M.-G. Bousser [France] ; J. Chalmers [Australie] ; F. Cambien [France] ; S. Macmahon [Australie]Source :
- Neurology [ 0028-3878 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Objective: The apolipoprotein E (APOE) polymorphism is an established risk factor for intracerebral hemorrhage (ICH) that is related to cerebral amyloid angiopathy in the white population. Among Asian populations, although ICH represents up to one third of all strokes and has high rates of mortality and morbidity, the role of the APOE polymorphism has not been well studied. Methods: The Perindopril Protection Against Recurrent Stroke Study (PROGRESS) was a randomized, double-blind, placebo-controlled trial of a blood pressure lowering regimen in subjects with prior cerebrovascular disease. APOE status was determined for 5,671 patients, including 2,148 Asians (38%). Results: During the 3.9 years of follow-up, ICH occurred in 99 patients. Overall, carrying an e2 or e4 allele of the APOE polymorphism was associated with an adjusted hazard ratio (HRa) of 1.85 (95% Cl = 1.24 to 2.76). In Asian patients the risk of ICH for e2 or e4 carriers was 2.11 (95% Cl = 1.28 to 3.47) and 1.48 (95% Cl = 0.76 to 2.87) in Europeans. Carriers of the e2 or e4 allele had an increased risk of both incident and recurrent ICH, and both cortical and deep ICH, and most risk estimates were higher in Asians than in Europeans. For both ethnic groups and for subtypes of ICH active treatment more than halved the risk of ICH and the treatment effects were not different in carriers of the e2 or e4 allele and in those with the e3e3 genotype. Conclusions: There is a strong association between APOE genotype and the risk of intracerebral hemorrhage (ICH). In Asian patients the role of APOE polymorphisms in ICH is much broader than was previously supposed.
Affiliations:
- Australie, France, Japon, États-Unis
- Nouvelle-Galles du Sud, Victoria (État), Île-de-France
- Melbourne, Paris, Sydney
- Université de Melbourne, Université de Sydney
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Tzourio</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U708</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>INSERM U708</wicri:noRegion><wicri:noRegion>INSERM U708</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Hôpital Lariboisière</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Hôpital Lariboisière</wicri:noRegion><wicri:noRegion>Department of Neurology, Hôpital Lariboisière</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Université Pierre et Marie Curie-Paris 6</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>The George Institute for International Health University of Sydney</s1><s3>AUS</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Arima, H" sort="Arima, H" uniqKey="Arima H" first="H." last="Arima">H. 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Godin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U708</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>INSERM U708</wicri:noRegion><wicri:noRegion>INSERM U708</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Université Pierre et Marie Curie-Paris 6</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Woodward, M" sort="Woodward, M" uniqKey="Woodward M" first="M." last="Woodward">M. 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Bousser</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Hôpital Lariboisière</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Hôpital Lariboisière</wicri:noRegion><wicri:noRegion>Department of Neurology, Hôpital Lariboisière</wicri:noRegion></affiliation></author><author><name sortKey="Chalmers, J" sort="Chalmers, J" uniqKey="Chalmers J" first="J." last="Chalmers">J. Chalmers</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>The George Institute for International Health University of Sydney</s1><s3>AUS</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Cambien, F" sort="Cambien, F" uniqKey="Cambien F" first="F." last="Cambien">F. 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Macmahon</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>The George Institute for International Health University of Sydney</s1><s3>AUS</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0225263</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0225263 INIST</idno><idno type="RBID">Pascal:08-0225263</idno><idno type="wicri:Area/PascalFrancis/Corpus">003619</idno><idno type="wicri:Area/PascalFrancis/Curation">002A27</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">003436</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">003436</idno><idno type="wicri:doubleKey">0028-3878:2008:Tzourio C:apoe:genotype:ethnicity</idno><idno type="wicri:Area/Main/Merge">009850</idno><idno type="wicri:Area/Main/Curation">008E98</idno><idno type="wicri:Area/Main/Exploration">008E98</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">APOE genotype, ethnicity, and the risk of cerebral hemorrhage</title><author><name sortKey="Tzourio, C" sort="Tzourio, C" uniqKey="Tzourio C" first="C." last="Tzourio">C. Tzourio</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U708</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>INSERM U708</wicri:noRegion><wicri:noRegion>INSERM U708</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Hôpital Lariboisière</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Hôpital Lariboisière</wicri:noRegion><wicri:noRegion>Department of Neurology, Hôpital Lariboisière</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Université Pierre et Marie Curie-Paris 6</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>The George Institute for International Health University of Sydney</s1><s3>AUS</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Arima, H" sort="Arima, H" uniqKey="Arima H" first="H." last="Arima">H. Arima</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Environmental Medicine Kyushu University</s1><s2>Fukuoka</s2><s3>JPN</s3><sZ>2 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Department of Environmental Medicine Kyushu University</wicri:noRegion></affiliation></author><author><name sortKey="Harrap, S" sort="Harrap, S" uniqKey="Harrap S" first="S." last="Harrap">S. Harrap</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Physiology University of Melbourne</s1><s3>AUS</s3><sZ>3 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Anderson, C" sort="Anderson, C" uniqKey="Anderson C" first="C." last="Anderson">C. Anderson</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>The George Institute for International Health University of Sydney</s1><s3>AUS</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Godin, O" sort="Godin, O" uniqKey="Godin O" first="O." last="Godin">O. Godin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U708</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>INSERM U708</wicri:noRegion><wicri:noRegion>INSERM U708</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Université Pierre et Marie Curie-Paris 6</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Woodward, M" sort="Woodward, M" uniqKey="Woodward M" first="M." last="Woodward">M. Woodward</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>The George Institute for International Health University of Sydney</s1><s3>AUS</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Mt Sinai Medical Center</s1><s2>New York, NY</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Mt Sinai Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Neal, B" sort="Neal, B" uniqKey="Neal B" first="B." last="Neal">B. Neal</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>The George Institute for International Health University of Sydney</s1><s3>AUS</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Bousser, M G" sort="Bousser, M G" uniqKey="Bousser M" first="M.-G." last="Bousser">M.-G. Bousser</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Hôpital Lariboisière</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Hôpital Lariboisière</wicri:noRegion><wicri:noRegion>Department of Neurology, Hôpital Lariboisière</wicri:noRegion></affiliation></author><author><name sortKey="Chalmers, J" sort="Chalmers, J" uniqKey="Chalmers J" first="J." last="Chalmers">J. Chalmers</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>The George Institute for International Health University of Sydney</s1><s3>AUS</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Cambien, F" sort="Cambien, F" uniqKey="Cambien F" first="F." last="Cambien">F. Cambien</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>INSERM U525</s1><s2>Paris</s2><s3>FRA</s3><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Macmahon, S" sort="Macmahon, S" uniqKey="Macmahon S" first="S." last="Macmahon">S. Macmahon</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>The George Institute for International Health University of Sydney</s1><s3>AUS</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebral hemorrhage</term><term>Genotype</term><term>Nervous system diseases</term><term>Risk factor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Hémorragie cérébrale</term><term>Pathologie du système nerveux</term><term>Génotype</term><term>Facteur risque</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: The apolipoprotein E (APOE) polymorphism is an established risk factor for intracerebral hemorrhage (ICH) that is related to cerebral amyloid angiopathy in the white population. Among Asian populations, although ICH represents up to one third of all strokes and has high rates of mortality and morbidity, the role of the APOE polymorphism has not been well studied. Methods: The Perindopril Protection Against Recurrent Stroke Study (PROGRESS) was a randomized, double-blind, placebo-controlled trial of a blood pressure lowering regimen in subjects with prior cerebrovascular disease. APOE status was determined for 5,671 patients, including 2,148 Asians (38%). Results: During the 3.9 years of follow-up, ICH occurred in 99 patients. Overall, carrying an e2 or e4 allele of the APOE polymorphism was associated with an adjusted hazard ratio (HR<sub>a</sub>) of 1.85 (95% Cl = 1.24 to 2.76). In Asian patients the risk of ICH for e2 or e4 carriers was 2.11 (95% Cl = 1.28 to 3.47) and 1.48 (95% Cl = 0.76 to 2.87) in Europeans. Carriers of the e2 or e4 allele had an increased risk of both incident and recurrent ICH, and both cortical and deep ICH, and most risk estimates were higher in Asians than in Europeans. For both ethnic groups and for subtypes of ICH active treatment more than halved the risk of ICH and the treatment effects were not different in carriers of the e2 or e4 allele and in those with the e3e3 genotype. Conclusions: There is a strong association between APOE genotype and the risk of intracerebral hemorrhage (ICH). In Asian patients the role of APOE polymorphisms in ICH is much broader than was previously supposed.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Japon</li><li>États-Unis</li></country><region><li>Nouvelle-Galles du Sud</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Melbourne</li><li>Paris</li><li>Sydney</li></settlement><orgName><li>Université de Melbourne</li><li>Université de Sydney</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Tzourio, C" sort="Tzourio, C" uniqKey="Tzourio C" first="C." last="Tzourio">C. Tzourio</name></noRegion><name sortKey="Bousser, M G" sort="Bousser, M G" uniqKey="Bousser M" first="M.-G." last="Bousser">M.-G. Bousser</name><name sortKey="Cambien, F" sort="Cambien, F" uniqKey="Cambien F" first="F." last="Cambien">F. Cambien</name><name sortKey="Godin, O" sort="Godin, O" uniqKey="Godin O" first="O." last="Godin">O. Godin</name><name sortKey="Godin, O" sort="Godin, O" uniqKey="Godin O" first="O." last="Godin">O. Godin</name><name sortKey="Tzourio, C" sort="Tzourio, C" uniqKey="Tzourio C" first="C." last="Tzourio">C. Tzourio</name><name sortKey="Tzourio, C" sort="Tzourio, C" uniqKey="Tzourio C" first="C." last="Tzourio">C. Tzourio</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Tzourio, C" sort="Tzourio, C" uniqKey="Tzourio C" first="C." last="Tzourio">C. Tzourio</name></region><name sortKey="Anderson, C" sort="Anderson, C" uniqKey="Anderson C" first="C." last="Anderson">C. Anderson</name><name sortKey="Chalmers, J" sort="Chalmers, J" uniqKey="Chalmers J" first="J." last="Chalmers">J. Chalmers</name><name sortKey="Harrap, S" sort="Harrap, S" uniqKey="Harrap S" first="S." last="Harrap">S. Harrap</name><name sortKey="Macmahon, S" sort="Macmahon, S" uniqKey="Macmahon S" first="S." last="Macmahon">S. Macmahon</name><name sortKey="Neal, B" sort="Neal, B" uniqKey="Neal B" first="B." last="Neal">B. Neal</name><name sortKey="Woodward, M" sort="Woodward, M" uniqKey="Woodward M" first="M." last="Woodward">M. Woodward</name></country><country name="Japon"><noRegion><name sortKey="Arima, H" sort="Arima, H" uniqKey="Arima H" first="H." last="Arima">H. Arima</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Woodward, M" sort="Woodward, M" uniqKey="Woodward M" first="M." last="Woodward">M. Woodward</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= APOE genotype, ethnicity, and the risk of cerebral hemorrhage
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